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MSKReport Online Newsletter February 19, 2009
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MSK Report News

BioPharm Business: Raptiva Pulled in EU After 3rd PML Case; FDA Warns US Docs
European regulators suspended sales of the psoriasis drug Raptiva after a 3rd PML death, and the FDA warned US doctors of a 4th suspected case...

BioPharm Business: FDA Gives Nod to Uloric (febuxostat), First New Gout Treatment in 40 Years
The US FDA approved 40 mg and 80 mg doses of Takeda Pharmaceutical's febuxostat (Uloric) for the chronic management of hyperuricemia in patients with gout...

Skin: Ustekinumab Reduces Psoriatic Arthritis Pain, Clears Lesions
Ustekinumab (CNTO 1275), a new monoclonal antibody that blocks interleukin (IL)-12 and IL-23 (IL-23), may help thwart the pain, swelling and lesions of psoriatic arthritis...

Arthritis: Some TNF Inhibitors Raise Shingles Risk in RA. Time to Vaccinate?
Anti-TNF monoclonal antibody drugs (adalimumab, infliximab) significantly increase herpes zoster risk in RA patients, and vaccination should be considered. Etanercept was not associated with increased herpes zoster risk...

BioPharm Business: La Jolla and Biomarin Dump Riquent, Cite "Futile" Phase 3 Lupus Data
La Jolla Pharmaceutical has ended work on Riquent (abetimus sodium)after the first interim efficacy analysis for the ASPEN Phase 3 lupus nephritis trial...