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Found 79 result(s) FROM 1963 pages containing the term 'spinal stenosis'.
Tuesday Apr 27, 2010
DePuy Spine Launches Expedium Vertebral Body Derotation Instrument Set
The set is designed to help surgeons correct spinal alignment and decrease rib rotation in patients with scoliosis...
Wednesday Apr 07, 2010
Surgeons Turn to Complex Spinal Procedures Despite Hazards
Complex surgical procedures to treat back pain have soared in popularity in recent years, but experts say they pose greater risks with no more benefits...
Wednesday Nov 18, 2009
FDA Wants Pain Pump Label Warnings
Chondrolysis follows continuous intra-articular local anesthetic infusion, FDA says...
Wednesday Oct 28, 2009
Third RA Patient Has PML After Rituximab
The FDA's MedWatch warning system reports that a third rheumatoid arthritis (RA) patient treated with Genentech's Rituxan (rituximab) has developed PML, this time without prior anti-TNF exposure...
Tuesday Aug 25, 2009
First RCTs Cast Doubt on Vertebroplasty Gains
The first 2 randomized, placebo-controlled trials of vertebroplasty for osteoporotic fractures show no significant benefits for the procedure...
Thursday Jul 09, 2009
Amgen's Denosumab Bests Zometa in Breast Cancer Patients
The first of three pivotal oncology trials comparing denosumab to Zometa in the advanced cancer setting meets primary and secondary endpoints...
Tuesday Jun 30, 2009
Assessment of Bone Growth Stimulator Is Mixed
Bone-morphogenic protein (BMP) is being increasingly used in the US to stimulate the creation of new bone during spinal fusion surgery, despite higher costs and complication rates...
Wednesday Jun 03, 2009
DHEA Intensifies Calcium, Vitamin D Effect on BMD
Adding DHEA to calcium and vitamin D significantly increases spine BMD in older women (but not in men) and might be a good thing, provided the women don't have family cancer risk and don't need to pass any sports doping tests...
Monday May 18, 2009
Sham, True Acupuncture Both Help Low Back Pain
Individually tailored acupuncture, standard acupuncture, and a sham procedure involving toothpicks at key points work better than usual care at relieving chronic low back pain...
Wednesday Apr 01, 2009
Analgesic Overdose Causes 21% of Deaths After Lumbar Fusions
Patients who had lumbar fusions for back pain were at greater risk of death in later years than those treated nonsurgically. The risk was particularly high in those who received instrumentation or intervertebral cage devices, and more than 1 in 5 deaths were due to analgesic overdose...
Tuesday Jan 13, 2009
Pilates Favorite: Multifidus Emerges As Key Muscle for Preventing Back Pain
The little multifidus muscle, beloved of Pilates exercise instructors but largely ignored in other settings, turns out to be key to spinal stability...
Wednesday Dec 10, 2008
US-Guided Synvisc, Steroids Ease Inoperable Shoulders
Ultrasound-guided hyaluronic acid and steroid offer an alternative for inoperable shoulder impingement syndrome and arthrosynovitis...
Monday Dec 08, 2008
Medtronic Challenges Lawsuit Over Spinal Implant
The family of a woman who died after having neck surgery with Infuse Bone Graft is suing Medtronic, the maker of the spinal implant, for promoting off-label use of their device...
Friday Nov 07, 2008
Studies Confirm, Extend Uses of MRI in Spondyloarthropathies
Severe romanus lesions in patients with back pain who are younger than 51 are very specific for spondyloarthropathy, and an MRI of just the sacroiliac joint is generally enough to diagnose nonradiographic axial SpA, regardless of the location of the back pain...
Wednesday Oct 15, 2008
Genentech Issues Dear Healthcare Provider Letter Regarding Case of PML in a Psoriasis Patient Under Long-Term Treatment With Raptiva®
The 70-year old patient had received Raptiva® (efalizumab) for >4 years to treat chronic plaque psoriasis before being diagnosed with progressive multifocal leukoencephalopathy...
Friday Sep 26, 2008
ASBMR Reports Show 68% Drop in Spinal Fractures With Denosumab, Stronger Effect on Bone Turnover Than With Alendronate, High Patient Preference
Studies reported at the 2008 ASBMR meeting showed that denosumab, which is given twice yearly, was as effective as the best competing agents at preventing osteoporotic fractures. Denosumab produced greater gains in BMD than alendronate and was preferred to once-weekly oral alendronate...
Friday Sep 19, 2008
Axial Biotech Initiates Clinical Field Test for ScoliScore™ AIS Prognostic Test
The ScoliScore™ AIS Prognostic Test can determine whether a child has a mild or more severe likelihood of curve progression, at the first presentation of symptoms...
Thursday Aug 28, 2008
Mesoblast Reports Preclinical Study Shows Allogeneic Stem Cells in Ewes are Safe, Effective for Cervical Spine Fusion; Therapy May Receive Boost From US FDA’s Recent Alert of Life-Threatening Complications Associated With rhBMP in Cervical Spine Fusions
Mesoblast is currently in phase II clinical trials for fusion of the lumbar spine and, based on these new results, will extend its market opportunity to cover the entire spectrum of spinal fusion. Subject to FDA approval, Mesoblast's therapy will eliminate the need for autograft...
Friday May 02, 2008
Icelandic and British Researchers ID Five New Osteoporosis Genes
New research spotlighting five genetic loci associated with bone mineral density (BMD) and fractures may provide insight into the biochemical pathways that underlie osteoporosis…
Tuesday Apr 22, 2008
Pain Management in Fibromyalgia
New treatments targeting central pain mechanisms may benefit patients suffering from chronic pain…
Monday Apr 14, 2008
Twin Spine Study Shows Genes, Not Injuries Cause Most Disc Problems
Researchers with the Twin Spine Study show that most degenerative back problems are linked to genes, not to aging, injuries, lifting, or driving. They also identified several genes involved...
Thursday Apr 10, 2008
The Days of Using Potent Anticoagulants to Prevent Pulmonary Embolism After Joint Arthroplasty May Be Numbered
Experts say that the routine use of potent anticoagulants to stave off pulmonary embolism after joint arthroplasty should be stopped because these blood thinners may actually increase mortality…
Wednesday Apr 02, 2008
DEXA Scans, Serum Testosterone, Vitamin D Tests Urged for Men Over 70
Osteoporosis in men is a common problem and requires more aggressive diagnosis, treatment, and monitoring of response...
Thursday Mar 20, 2008
Pain Relief for Osteoporosis Patients With Fractures
Vertobroplasty provides significant pain relief for osteoporosis patients with spinal fractures…
Thursday Feb 28, 2008
Acceleron, Celgene to Collaborate on Anabolic Bone Agent ACE-011, a Decoy Activin Receptor, for Cancer-Related Bone Loss
Acceleron Pharma and Celgene Corp announced a worldwide strategic collaboration for the development and commercialization of ACE-011, a novel bone-forming compound for the treatment of cancer-related bone loss...
Thursday Feb 14, 2008
Risedronate for Prevention of Bone Mineral Density Loss in Patients Receiving High-Dose Glucocorticoids
Risedronate improves spinal bone mineral density in patients receiving high-dose glucocorticoids...
Thursday Jan 31, 2008
Financial Ties Are Cited as Issue in Spine Study
Many of the spine surgeons who hailed the Prodisc® as a medical breakthrough had a financial interest in the new product…
Monday Jan 14, 2008
Drug Approved. Is Disease Real?
As Pfizer markets Lyrica® (pregabalin), the first approved medicine to treat fibromyalgia, doctors debate the legitimacy of the pain syndrome...
Tuesday Jan 08, 2008
Pain Relief for Some, With an Odd Tradeoff
A new device implanted near the spine offers relief for some chronic pain sufferers...
Friday Dec 07, 2007
Pfizer, Adolor Enter Into Exclusive Worldwide Collaboration to Develop and Commercialize Delta Opioid Receptor Agonists to Treat Range of Inflammatory, Neuropathic, and Acute Pain
Pfizer Inc and Adolor Corp, a leader in the area of novel, opioid receptor-targeted therapeutics, announced an exclusive worldwide collaboration to develop and commercialize delta opioid receptor agonist candidates, ADL5859 and ADL5747, for the treatment of pain...
Wednesday Dec 05, 2007
Drug Update: Infliximab
Researchers offer advice on reducing infliximab infusion times in RA, predicting who will respond, and what to expect in patients with ankylosing spondylitis...
Friday Nov 09, 2007
Efalizumab Suspected of Triggering Arthritis in Subset of Psoriasis Patients
A small subset of patients treated with efalizumab for severe plaque psoriasis developed new-onset psoriatic arthritis...
Friday Nov 02, 2007
Strontium Ranelate May Slow Osteoarthritis Progression
The osteoporosis drug strontium ranelate (Protelos®) may stop or slow the progression of osteoarthritis (OA) and also might alleviate back pain...
Thursday Oct 04, 2007
New Low Back Pain Guidelines Discourage Routine Imaging or Rest for Most Patients
New clinical guidelines for low back pain (LBP) discourage routine imaging in nonspecific LBP, set criteria for diagnostic imaging including MRI, recommend NSAIDs or acetaminophin as first-line drugs, urge the addition of nondrug therapy in difficult cases, and tell physicians to keep patients moving...
Friday Sep 21, 2007
TNF Blockade Slows But Does Not Stop X-Ray Progression in AS
Four-year follow-up data show that infliximab slows but does not inhibit radiographic progression in AS…
Friday Sep 07, 2007
Archus Orthopedics Completes World's First Lumbosacral Facet Joint Replacement
Archus Orthopedics, Inc, a privately-held company developing reconstructive implants to treat a variety of spine disorders resulting from degenerative changes in the facet joints, announced that it has successfully completed in Europe the first human implants of its new TFAS-LSâ„¢ system, representing the first ever facet joint replacement procedures performed at the lumbosacral spinal (LS) level...
Thursday Aug 30, 2007
Medtronic Receives FDA Approval for First Artificial Disc for Use in the Cervical Spine in the US
Medtronic, Inc, announced that it has received US FDA approval to market the PRESTIGE® Cervical Disc, the first artificial disc commercially available in the US for use in cervical disc arthroplasty or cervical artificial disc replacement...
Thursday Jul 05, 2007
Too Much Early, Aggressive Care Slows Recovery From Whiplash
Early, aggressive treatment of whiplash impedes recovery, and adding chiropractic to general medical care slows recuperation even more...
Wednesday Jun 13, 2007
Stopping AS May Require Earlier Use of TNF-Inhibitors
Inflammation in AS stops once the subchondral bone is eroded and the bone/cartilage interface disappears, so preventing bone erosion and syndesmophyte formation is likely to require early anti-inflammatory treatment, including TNF-inhibitors...
Thursday May 31, 2007
Studies Support Back Surgery Mainly for Nerve-Root-Associated Symptoms and Find Little Need to Rush to the OR
Lumbar-disk surgery for sciatica speeds pain relief but does not affect recovery at 1 year, but spinal fusion for lumbar degenerative spondylolisthesis with spinal stenosis was more effective than nonsurgical treatment...
Monday May 21, 2007
Risedronate Bests Alendronate for Fracture Reduction in REAL-World Setting
Patients receiving once-weekly risedronate have lower rates of hip and nonvertebral fractures during their first year of therapy than their counterparts who receive once-weekly alendronate...
Friday May 18, 2007
Xanthus Acquires Exclusive License to FLT3 Tyrosine Kinase Pathway Patent Estate as a Target for Treating Autoimmune Diseases
Xanthus Pharmaceuticals, Inc, a clinical-stage biopharmaceutical company that focuses on the discovery, development, acquisition, and commercialization of small-molecule therapeutics for the treatment of autoimmune diseases and cancer, announced that it has acquired an exclusive worldwide license to a patent estate from The Johns Hopkins University (JHU) for treating immune-related disorders by inhibiting the FLT3 receptor tyrosine kinase...
Thursday Feb 22, 2007
Zimmer and ISTO Start Clinical Trial of Neocartilage (DeNovo® ET Engineered Tissue Graft), a Novel Cartilage Regeneration Treatment
Zimmer Holdings, Inc, an orthopaedic leader in reconstructive and spinal implants, trauma, and related orthopaedic surgical products, and ISTO Technologies, Inc, a clinical-stage orthobiologic company that focuses on cell-based technology for the repair and regeneration of damaged cartilage in joints and spinal discs, announced the initiation of a clinical trial for Neocartilage, a living tissue-engineered graft...
Thursday Feb 15, 2007
Experts at the 74th Annual Meeting of the American Academy of Orthopaedic Surgeons Predict Clinically Useful Gene Therapy, Tissue Engineering Will Be Available "in 5 to 10 Years"
Presentations at the AAOS meeting include advances in both gene therapy and tissue-engineered products for cartilage, bone, and tendon repair...
Tuesday Feb 13, 2007
Wider Use of Spinal Cord Stimulation for Axial LBP Urged at Pain Medicine Meeting
Spinal cord stimulation is effective for axial low back pain (LBP) as well as for radiculopathy and should be more widely used for pain relief in LBP patients who have persistent pain associated with failed back surgery syndrome...
Tuesday Jan 30, 2007
Whiplash Rarely Results in Widespread Pain
New research shows that individuals with whiplash who report early symptoms of depression and those with severe neck injury are most at risk for widespread pain...
Tuesday Dec 19, 2006
FDA Warns of Fatal PML Risk With Rituximab Treatment
FDA reports deaths of two lupus patients treated with rituximab, warns of PML risk...
Thursday Dec 07, 2006
Leaning Back Might Help the Desk-Bound Dodge Back Pain
A positional MRI study of sitting postures and intervertebral disk morphology suggests that leaning back a bit rather than sitting up straight or slouching can greatly reduce strain on the lumbar spine and cut the risk of chronic back pain...
Wednesday Dec 06, 2006
Serum MMP-3 May Be Biomarker of Joint Damage in AS, MRI Accuracy Questioned
Measuring serum levels of metalloproteinase 3 (MMP3) may be an inexpensive yet accurate way for rheumatologists to predict which AS patients will develop joint damage, particularly in those with pre-existing radiographic damage...
Wednesday Nov 22, 2006
Still No Final Word on Diskectomy vs Nonoperative Treatment for HNP
New data show no dramatic difference between diskectomy and nonoperative management of lumbar disk herniation—suggesting that individual patient preferences should play a major role in choice of treatment— and that there is no great risk in delaying surgery.
Tuesday Nov 07, 2006
Study IDs Predictors of Poor Outcome in Enthesitis-Related Arthritis
Enthesitis-related arthritis (ERA) patients tend to have worse outcomes than children with other subtypes of juvenile idiopathic arthritis (JIA). Predictors of poor outcome include family history of related diseases, the presence of HLA-DRB1*08, the absence of a protective HLA subtype, and persistently elevated erythrocyte sedimentation rate (ESR)…
Tuesday Sep 12, 2006
CNS Uses p38, TNFα to Upregulate Joint Inflammatory Responses
The p38 MAP kinase links the central nervous system and peripheral responses via a pathway that includes TNF-α. Blocking those communications within the spinal cord by intrathecal administration of either a p38 inhibitor or etanercept dramatically reduces swelling, synovial inflammation, and joint destruction in an animal model of RA....
Wednesday Aug 23, 2006
Niche Use Seen for SSZ in Inflammatory Back Pain
SSZ may be useful in patients with inflammatory back pain who do not have peripheral arthritis... Braun J, et al. Ann Rheum Dis. 2006;65:1147-1153
Wednesday Jun 14, 2006
MRI Reveals Little in Low Back Pain
Routine use of MRI in early episodes of low back pain is probably a mistake... Carragee E. Presented at: American Pain Society 25th Annual Meeting; May 3–6, 2006; San Antonio, Tex.
Monday Jun 12, 2006
Abbott's Humira® Approved in European Union for Severe Ankylosing Spondylitis
Abbott Laboratories announced that Humira® (adalimumab) was approved by the European Commission for marketing in Europe as a treatment for severe, active ankylosing spondylitis...
Monday May 15, 2006
Infliximab Cools Spinal Inflammation in AS
Six months of infliximab significantly reduced MRI-proven sites of spinal inflammation in patients with ankylosing spondylitis... Braun J, et al. Arthritis Rheum. 2006;54:1646-1652.
Monday Mar 20, 2006
Use of Muscle-Derived Stem Cells May Revolutionize Treatment of OA
Due to their regenerative capabilities, muscle-derived stem cells may one day revolutionize the treatment of osteoarthritis, potentially staving off the need for joint replacement surgery in millions... Huard J, et al. Presented at: 52nd Annual Meeting of the Orthopaedic Research Society; March 18–22, 2006; Chicago, Ill. Workshop 1.
Tuesday Feb 14, 2006
Disease Activity and Severity Seen as Determinants in Starting Tumor Necrosis Factor-Alpha Blockers in Ankylosing Spondylitis Prior to Publication of ASAS Recommendations
Both disease activity and severity were determinants in starting tumor necrosis factor-alpha blockers in ankylosing spondylitis patients prior to the publication of the 2003 Assessment in AS (ASAS) international working group recommendations... Pham T, et al. Ann Rheum Dis [serial online]. February 7, 2006; doi:10.1136/ard.2005.042630
Monday Feb 13, 2006
BioMimetic Therapeutics Files for IPO
BioMimetic Therapeutics, Inc, of Franklin, Tennessee, announced that it has filed a registration statement with the US Securities and Exchange Commission...
Monday Feb 06, 2006
Archus Orthopedics Raises $35 Million in Series C Financing
Archus Orthopedics, Inc, of Redmond, Washington, announced that it has closed a $35 million round of Series C financing...
Wednesday Dec 21, 2005
EMG May Be Better Than MRI at Diagnosing Spinal Stenosis
Because it can test nerve function and determine the presence of nerve damage, electromyogram testing may be more effective than magnetic resonance imaging in diagnosing spinal stenosis as well as detecting neuromuscular diseases that mimic stenosis... Haig AJ, et al. Spine. In press.
Wednesday Nov 16, 2005
Zimmer Holdings Poised to Expand R&D Center
Zimmer Holdings, Inc, of Warsaw, Indiana, an industry leader in the design, development, manufacture, and marketing of reconstructive and spinal implants and related orthopaedic surgical products, has announced plans to expand its research and development capabilities and facilities in Warsaw
Wednesday Oct 05, 2005
New Bone Biopsy Data Support Safety of Dual-Acting Strontium Ranelate for Osteoporosis
A potentially dual-acting new osteoporosis medication, strontium ranelate, may safely decrease bone resorption while increasing bone formation, rebalancing bone turnover toward formation . . . Presented at: 27th Annual Meeting of the American Society for Bone and Mineral Research; September 23–27, 2005; Nashville, Tenn. Abstract 1084.
Tuesday Sep 27, 2005
Novel Method of Upfront Loading of Bisphosphonates Found to Improve Spinal Bone Mineral Density and Reduce Fractures
Upfront loading of oral or intravenous bisphosphonates followed by maintenance dosing may enhance the ability of these agents to reduce fracture risk compared with currently used dosing regimens... Presented at: 27th Annual Meeting of the American Society for Bone and Mineral Research; September 23-27, 2005; Nashville, Tennessee. Abstract M369.
Tuesday Sep 27, 2005
Mesoblast Limited to Start Human Orthopaedic Trial Using Adult Stem Cell Technology
Mesoblast Limited of Melbourne, Australia, a biotechnology company that develops adult mesenchymal precursor stem cell technology for the regeneration and repair of bone and cartilage, has announced...
Tuesday Sep 27, 2005
Competitive Technologies Licenses Bone Biomaterial to Soteira for Spinal Applications
Competitive Technologies, Inc (CTT), a technology transfer and licensing provider, has granted Soteira, Inc, of Dedham, Massachusetts...
Tuesday Sep 06, 2005
Aromatase Inhibitors Linked to Arthralgias
With increasing use of aromatase inhibitors as both a breast cancer treatment and preventive agent, rheumatologists should be aware of associated joint pain and musculoskeletal aching... Felson DT, Cummings SR. Arthritis Rheum. 2005;52:2594-2598.
Tuesday Aug 23, 2005
MRI Data Show Etanercept Reduces Spinal Lesions in AS, but Questions Remain
Etanercept therapy leads to the regression of spinal lesions in active ankylosing spondylitis and undifferentiated spondyloarthritis... Rudwaleit M, et al. Ann Rheum Dis. 2005;64:1305-1310
Tuesday Aug 09, 2005
Neuropsychiatric Syndromes in SLE Patients Are Complex and Underdiagnosed
Though neuropsychiatric (NP) syndromes, regardless of etiology, are common among patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), a new study suggests that lupus patients with a history of NP syndromes report more severe anxiety and depression as well as cognitive dysfunction, pointing to the need for earlier diagnosis of these nonspecific symptoms...J Rheumatol. 2005;32:1459-1466.
Thursday Aug 04, 2005
Scientists Develop New Technique to Grow Bone In Vivo
In a development that one day may revolutionize spinal and knee-replacement surgery and the treatment of osteoporosis, researchers at Vanderbilt University in Nashville, Tennessee, have demonstrated for the first time that healthy new bone can be grown in one part of the body to repair bony defects at another location... Stevens MM, et al. In vivo engineering of organs: The bone bioreactor. Proc Natl Acad Sci. 2005; scheduled to appear online before print. Available at: http://www.pnas.org/.
Wednesday Jun 22, 2005
Early Ankylosing Spondylitis Cohort Underscores Link Between Sustained Disease Activity and Progression
German Spondyloarthritis Inception Cohort (GESPIC) shows that sustained high disease activity during the early stages of AS, despite treatment with NSAIDs, may be an important prognostic indicator of disease progression, and may suggest a possible earlier role for TNF-blockade... Presented at: European Congress of Rheumatology of EULAR; June 8-11, 2005; Vienna, Austria.
Monday Jun 06, 2005
Trials Outline Effective Strategies for the Use of Existing Therapies in Ankylosing Spondylitis
Four new studies highlight ways to use non-steroidals, biologics, and methotrexate in ankylosing spondylitis. Marzo-Ortega H, et al. Ann Rheum Dis. 2005 May 26; [Epub ahead of print].
Tuesday May 24, 2005
Rehabilitation Is as Beneficial and More Cost-Effective Than Spinal Fusion in Chronic Low Back Pain Patients
Contrary to previous reports and often physicians' advice, rehabilitation utilizing cognitive behavior principles is as effective as fusion for chronic low back pain, and should be offered as a first-line therapy...Fairbank J, et al. BMJ. May 23, 2005; [Epub ahead of print].
Tuesday May 03, 2005
African-American Women Have Lower Risk of Fractures than Caucasians Across All Levels of Bone Mineral Density
New data suggests the need for race specific normative databases to define osteoporosis...Cauley JA, et al. JAMA 2005;293:2102-2108.
Monday Apr 25, 2005
Novel Osteoinductive Molecule May Speed Fracture Healing and Enhance Spinal Fusion
A newly discovered osteoinductive protein promises greater specificity than bone morphogenetic proteins (BMPs)...UCLA Henry Samueli School of Engineering and Applied Science [press release]. April 21, 2005.
Friday Feb 25, 2005
The Future of Spinal Surgery: Artificial Discs and Bone Growth Factors Show Promise
PCM cervical discs, Charité lumbar discs, and BMPs demonstrate improved outcomes and greater patient satisfaction as alternatives to traditional spinal fusion surgery...72nd Annual Meeting of the American Academy of Orthopedic Surgeons; February 23, 2005.
Wednesday Nov 24, 2004
Gender Bias May Exist in the Recognition and Treatment of Osteoporosis in Men
Although men have higher vertebral fracture rates than women, they may not get screening and treatment for osteoporosis as often or as early... Sawka AM, et al. J Rheumatol. 2004;31:1993-1995.
Friday Oct 22, 2004
Research Shows Benefits of TNF-α Blockers in Treating Ankylosing Spondylitis
Studies involving etanercept, infliximab, and adalimumab consistently show long-term benefits with regard to disease activity, function, and spinal mobility... Davis JC, et al. Presented at: Annual Meeting of the American College of Rheumatology; October 20, 2004; San Antonio, Tex.
Friday Oct 22, 2004
Research Shows Benefits of TNF-α Blockers in Treating Ankylosing Spondylitis
Studies involving etanercept, infliximab, and adalimumab consistently show long-term benefits with regard to disease activity, function, and spinal mobility... Davis JC, et al. Presented at: Annual Meeting of the American College of Rheumatology; October 20, 2004; San Antonio, Tex.
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