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Found 18 result(s) FROM 1963 pages containing the term 'scleroderma'.
Thursday Sep 24, 2009
Rituximab Improves SSc Lung Function
A small pilot study has established proof-of-principle that rituximab improves lung function in scleroderma...
Monday Nov 24, 2008
Scleroderma Stem Cell Transplants Advance, Phase III Studies Recruiting Patients
Pilot data on systemic sclerosis (SSc) patients treated with autologous stem cell transplants suggest durable improvements in skin thickening and lung function. Phase III randomized trials are still open to enrollment...
Monday Oct 20, 2008
Gleevec/CYC Combo Emerging as Novel Approach for Scleroderma Lung Disease
Adding the oncology drug imatinib (Gleevec®) to cyclophosphamide offers a 2-pronged strategy that might be effective in scleroderma-associated pulmonary complications...
Tuesday Sep 30, 2008
Microparticles May Be Big Players in Systemic Scleroderma Disease Activity
Microparticles—small, membrane, coated vesicles—found in the blood of systemic scleroderma patients might not be inert debris…
Friday Jul 25, 2008
New High-Resolution Device Aids Finger MRI in Scleroderma
High-resolution magnetic resonance angiography (micro-MRA) can readily measure vascular disease of fingers in systemic sclerosis…
Wednesday Nov 14, 2007
New Topical Nitroglycerin for Raynaud's Phenomenon Reported at ACR
A new topical formulation of nitroglycerine that is not absorbed systemically significantly reduced symptoms in over 40% of patients with Raynaud's phenomenon...
Tuesday Oct 09, 2007
Sitaxsentan May Offer Alternative to Bosentan for PAH in Connective Tissue Disease Patients
Sitaxsentan improved 6-minute walk distance and quality of life in connective tissue disease patients who also have PAH...
Tuesday Jan 16, 2007
Preclinical Data Support Trial of Gleevec in SSc
The anticancer drug imatinib (Gleevec) can reduce production of extracellular matrix in SSc dermal fibroblasts, has prevented experimental dermal fibrosis in an animal model, and is seen as a "highly promising candidate" for treatment of SSc...
Thursday Dec 07, 2006
High-Dose Immune Suppression With or Without Stem Cell Transplants For Systemic Sclerosis
Studies are evaluating stem cell transplantation as a potential treatment for autoimmune disease, however, researchers sharply disagree regarding myeloablative vs nonmyeloablative approaches and whether stem cells are really necessary...
Tuesday Nov 14, 2006
Non-Myeloablative Stem Cell Transplants Safe, Effective in Scleroderma
A pilot study of a non-myeloablative hematopoietic stem cell transplantation regimen for patients with severe scleroderma reports 90% overall survival and 70% progression-free survival at 2 years…Barr WG, et al. Presented at: ACR 2006 Meeting.
Monday Nov 13, 2006
Shortfall of Academic Rheumatologists May Jeopardize Specialty's Future
ACR President Mary K. Crow, MD, calls for solutions to help academic medical centers recruit and retain talented rheumatologists... Presented at: ACR 2006 Meeting.
Monday Jul 17, 2006
LTKfarma Starts Operations With Lead Product for Autoimmune Diseases and Leukemia Already in Phase I/II, Names Advisory Board
LTKfarma, a biopharmaceutical company founded in March 2006 and focused on developing and marketing cell therapy products derived from modified T-cells to treat autoimmune diseases and leukemia announced its creation and the appointment of its advisory board....
Tuesday Jun 27, 2006
Bosentan Prevents Digital Ulcers, Improves Heart Function in Systemic Sclerosis
Bosentan reduces digital ulcer risk and improves heart function in systemic sclerosis patients... Allanore Y, et al. Presented at: EULAR 2006 Meeting; June 21–34, 2006; Amsterdam, The Netherlands. Abstract OP0120.
Wednesday Apr 26, 2006
Infliximab Suspected of Worsening Rare MTX Lung Problem
Interstitial pneumonitis occurs in less than 1% of patients treated with methotrexate (MTX), but a recent case report suggests that adding infliximab might increase lung toxicity risk in certain vulnerable patients... Villeneuve E, et al. J Rheumatol. 2006 Apr 15; [Epub ahead of print]
Thursday Jan 12, 2006
Three Months of Bosentan Therapy Improves Function in SSc-PAH Patients
Three Months of Bosentan Therapy Improves Function in SSc-PAH Patients
Wednesday Jan 11, 2006
Repligen and University of Michigan File Infringement Complaint Against BMS Over Orencia®
Repligen Corporation of Waltham, Massachusetts, announced that Repligen and the University of Michigan (UM) have filed a joint complaint against Bristol-Myers Squibb Corporation (BMS) for infringement of a US patent...
Friday Nov 04, 2005
Study Provides Additional Clues to the Causes of Systemic Sclerosis and the Potential Efficacy of Paclitaxel
New research in a murine model points to the ability of low-dose paclitaxel (Taxol®) to modulate transforming growth factor-beta (TGF-ß) and lessen fibrosis in systemic sclerosis patients, findings that also provide additional clues to the pathogenesis of the disease... Liu X, et al. PloS Med. 2005;2:e354
Wednesday Aug 25, 2004
Eighth International Scleroderma Meeting Reflects Increased Interest
Research on etiology and potential therapeutic targets were highlights of the Eighth International Workshop on Scleroderma Research.
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